![]() ![]() ![]() In the Appendix, we present, in the framework of Quantum Field Theory (QFT), water as a biphasic liquid and how its coherent fraction can be affected by uwf-EM signals while at the same time resolving the “kT paradox”. Such up- respectively down-regulation of corresponding genes are strong indicators of an EM-induced hormetic effect that influences the epigenomic landscape of HDFs. We could demonstrate that a 10 min uwf-EM exposure (prior to incubation) increases type-1 collagen and modulates elastin in human fibroblasts cultured up to 96 h, while at the same time reduces IL-6, TNF-α and MMP-1 (the later three being statistically significant). Thus, the aim of this study is twofold, to i) investigate the extent of this modulating effect using Human Dermal Fibroblasts (HDF)-cells, and ii) analyse molecular rejuvenation markers therein. The fractal nature of such EM-signals relates to the self-similar property by which a “cut-out” and magnified piece of this signal reveals again the original. Such ultra-/very-low frequency (U/VLF) signals (few nT in intensity and within 0.5–30 kHz) interact with aqueous solutions in living systems. One of these methods makes use of ultra-weak fractal electromagnetic (uwf-EM) signals. Past studies showed that anti-inflammatory capabilities could be induced via non-chemical means. Recent studies have shown that collagen-degrading matrix metalloproteinase (MMP-1) is produced by fibroblasts in response to chronoaging, which in human dermal fibroblasts leads to the release of proinflammatory cytokines. Skin aging is primarily associated with the alterations in dermal extracellular matrix, in particular a decrease in collagen type-1 content. ![]()
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